[Abstract]
Combinatorial material synthesis is a powerful approach for creating composite material libraries
for the high-throughput screening of cell–material interactions. Although current combinatorial
screening platforms have been tremendously successful in identifying target (termed “hit”) 河南省人民医院妇科郭玉琪
materials from composite material libraries, new material synthesis approaches are needed to
further optimize the concentrations and blending ratios of the component materials. Here we
employed a microfluidic platform to rapidly synthesize composite materials containing crossgradients
of gelatin and chitosan for investigating cell–biomaterial interactions. The microfluidic
synthesis of the cross-gradient was optimized experimentally and theoretically to produce
quantitatively controllable variations in the concentrations and blending ratios of the two
components. The anisotropic chemical compositions of the gelatin/chitosan cross-gradients were
characterized by Fourier transform infrared spectrometry and X-ray photoelectron spectrometry.
The three-dimensional (3D) porous gelatin/chitosan cross-gradient materials were shown to
regulate the cellular morphology and proliferation of smooth muscle cells (SMCs) in a gradientdependent
manner. We envision that our microfluidic cross-gradient platform may accelerate the
material development processes involved in a wide range of biomedical applications.
[Keywords]cross gradient; microfluidics; cell–biomaterial interactions
郭玉琪主任医师 教授
北京大学第三人民医院
擅长：不孕不育、优生优育、复发性流产、月经不调及更年期综合征等内分泌性疾病的诊断和治疗
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检查单解读Microfluidic Synthesis of Composite Cross-Gradient Materials
2011-07-18 19:18 发布
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