Biochem Biophys Res Commun. 2010 Jul 9;397(4):633-6. Epub 2010 Jun 10.
Voltage-dependent anion channel in mammalian spermatozoa.
Liu B, Zhang W, Wang Z.
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Abstract
Voltage-dependent anion channel (VDAC) is a multi-functional channel protein in the mitochondrial outer membrane of all eukaryotes. It is involved in extensive physiological and pathophysiological processes. However there is only scant information about VDAC in mammalian reproduction, fertility and development in the past. It is now recognized through recent studies that VDAC is present in male mammalian germinal tissues and cells, and plays crucial roles in spermatogenesis, sperm maturation and fertilization. This review will discuss the presence, localization and function of VDAC in mammalian spermatozoa. 江苏省人民医院泌尿外科王增军